Vesicular assembly and thermo-responsive vesicle-to-micelle transition from an amphiphilic random copolymer.
نویسندگان
چکیده
Vesicular assembly from a thermo-responsive amphiphilic random copolymer is reported. Vesicle-to-micelle transition above a critical morphology transition temperature (CMTT) resulted in selective triggered release of encapsulated hydrophilic guests over hydrophobic ones. The aggregation pattern of a control polymer indicated a defined role of the methacrylamide groups in the polymer backbone for such unprecedented self-assembly from a simple polymer.
منابع مشابه
Controlled nanogel and macrogel structures from self-assembly of a stimuli-responsive amphiphilic block copolymer.
RAFT polymerization was utilized to prepare an amphiphilic block copolymer containing both hydrophilic and hydrophobic segments. The self-assembly behavior of the block copolymer into nano-scale particulate structures was studied in both water and polar organic solvents. Uniform micelle assemblies were stabilized by reaction within the hydrophobic core, which contained pendant azide groups, thr...
متن کاملPhoto, pH, and thermo triple-responsive spiropyran-based copolymer nanoparticles for controlled release.
A spiropyran-based amphiphilic random copolymer was synthesized and self-assembled into photo-, pH-, and thermo-responsive micellar nanoparticles. The triple-stimuli triggered morphological changes of the nanoparticles were revealed by TEM and DLS. Highly efficient controlled release of encapsulated molecules, coumarin 102, from the nanoparticles under stimulation of UV light, acid and the comb...
متن کاملTheory of the Flower Micelle Formation of Amphiphilic Random and Periodic Copolymers in Solution
The mixing Gibbs energy ∆gm for the flower-micelle phase of amphiphilic random and periodic (including alternating) copolymers was formulated on the basis of the lattice model. The formulated ∆gm predicts (1) the inverse proportionality of the aggregation number to the degree of polymerization of the copolymer, (2) the increase of the critical micelle concentration with decreasing the hydrophob...
متن کاملAmphiphilic Block Copolymer Nano-micelles: Effect of Length Ratio of the Hydrophilic Block
Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...
متن کاملReversible pH- and solvent-responsive micelle-mediated self-assembly of platinum(II) terpyridyl-based metallo-supramolecular diblock copolymers.
An amphiphilic platinum(II)-containing diblock copolymer, with pH- and solvent-responsive micellization properties that could induce drastic UV-vis and emission spectral changes via modulation of Pt...Pt and pi-pi stacking interactions, has been demonstrated in both aqueous and organic media.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 47 46 شماره
صفحات -
تاریخ انتشار 2011